TY - JOUR
T1 - The human genetics of eating disorders
T2 - Lessons from the leptin/melanocortin system
AU - Costa, Jessica Lynn
AU - Brennen, Miles B.
AU - Hochgeschwender, Ute
N1 - Funding Information:
This work was funded by the generous support of the Eleanor Roosevelt Institute Board of Trustees.
PY - 2002
Y1 - 2002
N2 - Genetic analysis of eating disorders is complex phenotypically and genotypically. As seen in the leptin/melanocortin system, however, the results can lead to a deeper understanding and to new therapies. Benefits are expected for eating disorders that stem from genetic and psychologic causes. Finally, an awareness of possible genetic causes of eating disorders will help determine the causes - and thus the treatments - in children and adolescents with eating disorders, as exemplified by obese patients with mutations in the POMC, PC1, leptin, and MC4R loci.
AB - Genetic analysis of eating disorders is complex phenotypically and genotypically. As seen in the leptin/melanocortin system, however, the results can lead to a deeper understanding and to new therapies. Benefits are expected for eating disorders that stem from genetic and psychologic causes. Finally, an awareness of possible genetic causes of eating disorders will help determine the causes - and thus the treatments - in children and adolescents with eating disorders, as exemplified by obese patients with mutations in the POMC, PC1, leptin, and MC4R loci.
UR - http://www.scopus.com/inward/record.url?scp=0035998981&partnerID=8YFLogxK
U2 - 10.1016/S1056-4993(01)00013-X
DO - 10.1016/S1056-4993(01)00013-X
M3 - Review article
C2 - 12109327
AN - SCOPUS:0035998981
SN - 1056-4993
VL - 11
SP - 387
EP - 397
JO - Child and Adolescent Psychiatric Clinics of North America
JF - Child and Adolescent Psychiatric Clinics of North America
IS - 2
ER -