The identification of monoclonality in human aberrant crypt foci

I. Mei Siu; Dan R. Robinson; Stuart Schwartz; Hsing Jien Kung; Thomas G. Pretlow; Robert B. Petersen; Theresa P. Pretlow

The identification of monoclonality in human aberrant crypt foci

I. Mei Siu, Dan R. Robinson, Stuart Schwartz, Hsing Jien Kung, Thomas G. Pretlow, Robert B. Petersen, Theresa P. Pretlow

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103 Scopus citations

Abstract

Malignant neoplasms, including colon cancers, are thought to arise from a single initiated progenitor cell. Aberrant crypt foci (ACF) are putative precursors of at least some colon cancers. The pattern of X chromosomal inactivation, which is identified by the differential methylation of a site near a polymorphic CAG repeat in the androgen receptor gene, was used to determine the clonality status of 11 ACF from eight female patients. Ten of 11 ACF were found to be monoclonal aberrations. The eleventh ACF appeared monoclonal, but nonrandom inactivation of the X chromosome was also seen in normal crypts from this patient. These results clearly demonstrate that: (a) a high percentage of ACF lesions are neoplastic rather than hyperplastic; and (b) ACF are the earliest identified neoplastic lesions in the colon.

Original language	English
Pages (from-to)	63-66
Number of pages	4
Journal	Cancer Research
Volume	59
Issue number	1
State	Published - Jan 1 1999

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title = "The identification of monoclonality in human aberrant crypt foci",

abstract = "Malignant neoplasms, including colon cancers, are thought to arise from a single initiated progenitor cell. Aberrant crypt foci (ACF) are putative precursors of at least some colon cancers. The pattern of X chromosomal inactivation, which is identified by the differential methylation of a site near a polymorphic CAG repeat in the androgen receptor gene, was used to determine the clonality status of 11 ACF from eight female patients. Ten of 11 ACF were found to be monoclonal aberrations. The eleventh ACF appeared monoclonal, but nonrandom inactivation of the X chromosome was also seen in normal crypts from this patient. These results clearly demonstrate that: (a) a high percentage of ACF lesions are neoplastic rather than hyperplastic; and (b) ACF are the earliest identified neoplastic lesions in the colon.",

author = "Siu, {I. Mei} and Robinson, {Dan R.} and Stuart Schwartz and Kung, {Hsing Jien} and Pretlow, {Thomas G.} and Petersen, {Robert B.} and Pretlow, {Theresa P.}",

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T1 - The identification of monoclonality in human aberrant crypt foci

AU - Siu, I. Mei

AU - Robinson, Dan R.

AU - Schwartz, Stuart

AU - Kung, Hsing Jien

AU - Pretlow, Thomas G.

AU - Petersen, Robert B.

AU - Pretlow, Theresa P.

PY - 1999/1/1

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N2 - Malignant neoplasms, including colon cancers, are thought to arise from a single initiated progenitor cell. Aberrant crypt foci (ACF) are putative precursors of at least some colon cancers. The pattern of X chromosomal inactivation, which is identified by the differential methylation of a site near a polymorphic CAG repeat in the androgen receptor gene, was used to determine the clonality status of 11 ACF from eight female patients. Ten of 11 ACF were found to be monoclonal aberrations. The eleventh ACF appeared monoclonal, but nonrandom inactivation of the X chromosome was also seen in normal crypts from this patient. These results clearly demonstrate that: (a) a high percentage of ACF lesions are neoplastic rather than hyperplastic; and (b) ACF are the earliest identified neoplastic lesions in the colon.

AB - Malignant neoplasms, including colon cancers, are thought to arise from a single initiated progenitor cell. Aberrant crypt foci (ACF) are putative precursors of at least some colon cancers. The pattern of X chromosomal inactivation, which is identified by the differential methylation of a site near a polymorphic CAG repeat in the androgen receptor gene, was used to determine the clonality status of 11 ACF from eight female patients. Ten of 11 ACF were found to be monoclonal aberrations. The eleventh ACF appeared monoclonal, but nonrandom inactivation of the X chromosome was also seen in normal crypts from this patient. These results clearly demonstrate that: (a) a high percentage of ACF lesions are neoplastic rather than hyperplastic; and (b) ACF are the earliest identified neoplastic lesions in the colon.

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The identification of monoclonality in human aberrant crypt foci

Abstract

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