The influence of overweight and obesity on maternal soluble fms-like tyrosine kinase 1 and its relationship with leptin during pregnancy

Jennifer K. Straughen, Dawn P. Misra, Pawan Kumar, Vinod K. Misra

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

We studied obesity-related differences in the relation of maternal levels of leptin to levels of soluble fms-like tyrosine kinase 1 (sFlt1), an antiangiogenic protein that influences placentation and risk of adverse pregnancy outcomes. In a prospective cohort of 286 gravidas, we measured maternal serum levels of sFlt1 and leptin at 5 time points across pregnancy. Analyses stratified on prepregnancy body mass index (<25 vs ≥25) were done using mixed linear models. The mean leptin concentrations were significantly higher in overweight/obese compared to normal-weight women, while mean sFlt1 levels in second and third trimester were significantly higher in normal weight compared to overweight/obese women. The relationship between sFlt1 and leptin differed between the 2 strata. After controlling for maternal weight, a 1 ng/mL increase in leptin was associated with an 19.4 pg/mL increase in sFlt1 (P =.01) in normal-weight women, while leptin was not associated with sFlt1 (β = 1.1, P =.75) in overweight/obese women. Such differences suggest that metabolic differences in overweight/obese women compared to their normal weight peers may differentially impact the physiologic changes during pregnancy.

Original languageEnglish
Pages (from-to)269-275
Number of pages7
JournalReproductive Sciences
Volume20
Issue number3
DOIs
StatePublished - Mar 2013

Keywords

  • Flt1 protein
  • angiogenic factors
  • leptin
  • longitudinal analysis
  • obesity
  • pregnancy

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