TY - JOUR
T1 - Therapeutic Hypothermia
T2 - How Can We Optimize This Therapy to Further Improve Outcomes?
AU - Natarajan, Girija
AU - Laptook, Abbot
AU - Shankaran, Seetha
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/6
Y1 - 2018/6
N2 - Neonatal hypoxic-ischemic encephalopathy remains associated with considerable death and disability. In multiple randomized controlled trials, therapeutic hypothermia for neonatal moderate or severe hypoxic-ischemic encephalopathy among term infants has been shown to be safe and effective in reducing death and disability in survivors. In this article, the current status of infant and childhood outcomes following this therapy is reviewed. The clinical approaches that may help to optimize this innovative neuroprotective therapy are presented.
AB - Neonatal hypoxic-ischemic encephalopathy remains associated with considerable death and disability. In multiple randomized controlled trials, therapeutic hypothermia for neonatal moderate or severe hypoxic-ischemic encephalopathy among term infants has been shown to be safe and effective in reducing death and disability in survivors. In this article, the current status of infant and childhood outcomes following this therapy is reviewed. The clinical approaches that may help to optimize this innovative neuroprotective therapy are presented.
KW - Cooling
KW - Hypoxic-ischemic encephalopathy
KW - Neonate
UR - http://www.scopus.com/inward/record.url?scp=85042357549&partnerID=8YFLogxK
U2 - 10.1016/j.clp.2018.01.010
DO - 10.1016/j.clp.2018.01.010
M3 - Review article
C2 - 29747886
AN - SCOPUS:85042357549
SN - 0095-5108
VL - 45
SP - 241
EP - 255
JO - Clinics in Perinatology
JF - Clinics in Perinatology
IS - 2
ER -