Thermal decomposition of a generation 4.5 PAMAM dendrimer platinum drug conjugate

B. A. Howell; D. Fan; Leela Rakesh

doi:10.1007/s10973-005-7333-0

Thermal decomposition of a generation 4.5 PAMAM dendrimer platinum drug conjugate

B. A. Howell, D. Fan, Leela Rakesh

Mathematics

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

A nanoscale multivalent platinum drug based on a poly(amidoamine) [PAMAM] dendrimer (generation 4.5, carboxylate surface) has been synthesized and fully characterized using a variety of spectroscopic, chromatographic and thermal methods. Treatment of the dendrimer with an aqueous solution containing an excess diaquo(cis-1,2-diaminocyclohexane)platinum(II) produces a conjugate containing approximately forty (diaminocyclohexane)platinum(II) moieties at the surface of the dendrimer. This material undergoes smooth two-stage thermal decomposition to provide residual platinum oxide reflecting the platinum loading in the drug.

Original language	English
Pages (from-to)	17-20
Number of pages	4
Journal	Journal of Thermal Analysis and Calorimetry
Volume	85
Issue number	1
DOIs	https://doi.org/10.1007/s10973-005-7333-0
State	Published - Jul 2006

Keywords

Dendrimer-based organoplatinum drugs
Drug delivery
Polymeric drugs
Thermal decomposition
Time-release drugs

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10.1007/s10973-005-7333-0

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title = "Thermal decomposition of a generation 4.5 PAMAM dendrimer platinum drug conjugate",

abstract = "A nanoscale multivalent platinum drug based on a poly(amidoamine) [PAMAM] dendrimer (generation 4.5, carboxylate surface) has been synthesized and fully characterized using a variety of spectroscopic, chromatographic and thermal methods. Treatment of the dendrimer with an aqueous solution containing an excess diaquo(cis-1,2-diaminocyclohexane)platinum(II) produces a conjugate containing approximately forty (diaminocyclohexane)platinum(II) moieties at the surface of the dendrimer. This material undergoes smooth two-stage thermal decomposition to provide residual platinum oxide reflecting the platinum loading in the drug.",

keywords = "Dendrimer-based organoplatinum drugs, Drug delivery, Polymeric drugs, Thermal decomposition, Time-release drugs",

author = "Howell, {B. A.} and D. Fan and Leela Rakesh",

note = "Funding Information: Partial support of this work by the Army Research Laboratory (ARL DAAL-01-1996-02-044) is gratefully acknowledged.",

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T1 - Thermal decomposition of a generation 4.5 PAMAM dendrimer platinum drug conjugate

AU - Howell, B. A.

AU - Fan, D.

AU - Rakesh, Leela

N1 - Funding Information: Partial support of this work by the Army Research Laboratory (ARL DAAL-01-1996-02-044) is gratefully acknowledged.

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AB - A nanoscale multivalent platinum drug based on a poly(amidoamine) [PAMAM] dendrimer (generation 4.5, carboxylate surface) has been synthesized and fully characterized using a variety of spectroscopic, chromatographic and thermal methods. Treatment of the dendrimer with an aqueous solution containing an excess diaquo(cis-1,2-diaminocyclohexane)platinum(II) produces a conjugate containing approximately forty (diaminocyclohexane)platinum(II) moieties at the surface of the dendrimer. This material undergoes smooth two-stage thermal decomposition to provide residual platinum oxide reflecting the platinum loading in the drug.

KW - Dendrimer-based organoplatinum drugs

KW - Drug delivery

KW - Polymeric drugs

KW - Thermal decomposition

KW - Time-release drugs

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Thermal decomposition of a generation 4.5 PAMAM dendrimer platinum drug conjugate

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