Thermal decomposition of a generation 4.5 PAMAM dendrimer platinum drug conjugate

B. A. Howell, D. Fan, Leela Rakesh

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20 Scopus citations


A nanoscale multivalent platinum drug based on a poly(amidoamine) [PAMAM] dendrimer (generation 4.5, carboxylate surface) has been synthesized and fully characterized using a variety of spectroscopic, chromatographic and thermal methods. Treatment of the dendrimer with an aqueous solution containing an excess diaquo(cis-1,2-diaminocyclohexane)platinum(II) produces a conjugate containing approximately forty (diaminocyclohexane)platinum(II) moieties at the surface of the dendrimer. This material undergoes smooth two-stage thermal decomposition to provide residual platinum oxide reflecting the platinum loading in the drug.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalJournal of Thermal Analysis and Calorimetry
Issue number1
StatePublished - Jul 2006


  • Dendrimer-based organoplatinum drugs
  • Drug delivery
  • Polymeric drugs
  • Thermal decomposition
  • Time-release drugs


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