Transcription factor ZNF148 is a negative regulator of human muscle differentiation

Jesse Bakke, William C. Wright, Anthony E. Zamora, Su Sien Ong, Yue Ming Wang, Jessica D. Hoyer, Christopher T. Brewer, Paul G. Thomas, Taosheng Chen

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in human muscle cell differentiation. Downregulation of ZNF148 drives the formation of a muscle phenotype with rapid expression of myosin heavy chain, even in proliferative conditions. This phenotype was most likely mediated by the robust and swift upregulation of MYOD and MEF2C.

Original languageEnglish
Article number8138
JournalScientific Reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2017

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