Transcription factor ZNF148 is a negative regulator of human muscle differentiation

Jesse Bakke; William C. Wright; Anthony E. Zamora; Su Sien Ong; Yue Ming Wang; Jessica D. Hoyer; Christopher T. Brewer; Paul G. Thomas; Taosheng Chen

doi:10.1038/s41598-017-08267-5

Transcription factor ZNF148 is a negative regulator of human muscle differentiation

Jesse Bakke, William C. Wright, Anthony E. Zamora, Su Sien Ong, Yue Ming Wang, Jessica D. Hoyer, Christopher T. Brewer, Paul G. Thomas, Taosheng Chen

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in human muscle cell differentiation. Downregulation of ZNF148 drives the formation of a muscle phenotype with rapid expression of myosin heavy chain, even in proliferative conditions. This phenotype was most likely mediated by the robust and swift upregulation of MYOD and MEF2C.

Original language	English
Article number	8138
Journal	Scientific Reports
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41598-017-08267-5
State	Published - Dec 1 2017

Access to Document

10.1038/s41598-017-08267-5

Cite this

@article{a4ae0ec57bbb40fa94f5e911c5ccc258,

title = "Transcription factor ZNF148 is a negative regulator of human muscle differentiation",

abstract = "Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in human muscle cell differentiation. Downregulation of ZNF148 drives the formation of a muscle phenotype with rapid expression of myosin heavy chain, even in proliferative conditions. This phenotype was most likely mediated by the robust and swift upregulation of MYOD and MEF2C.",

author = "Jesse Bakke and Wright, {William C.} and Zamora, {Anthony E.} and Ong, {Su Sien} and Wang, {Yue Ming} and Hoyer, {Jessica D.} and Brewer, {Christopher T.} and Thomas, {Paul G.} and Taosheng Chen",

note = "Publisher Copyright: {\textcopyright} 2017 The Author(s).",

year = "2017",

month = dec,

day = "1",

doi = "10.1038/s41598-017-08267-5",

language = "English",

volume = "7",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "SCIENTIFIC REPORTS",

number = "1",

}

TY - JOUR

T1 - Transcription factor ZNF148 is a negative regulator of human muscle differentiation

AU - Bakke, Jesse

AU - Wright, William C.

AU - Zamora, Anthony E.

AU - Ong, Su Sien

AU - Wang, Yue Ming

AU - Hoyer, Jessica D.

AU - Brewer, Christopher T.

AU - Thomas, Paul G.

AU - Chen, Taosheng

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in human muscle cell differentiation. Downregulation of ZNF148 drives the formation of a muscle phenotype with rapid expression of myosin heavy chain, even in proliferative conditions. This phenotype was most likely mediated by the robust and swift upregulation of MYOD and MEF2C.

AB - Muscle differentiation is a complex process in which muscle progenitor cells undergo determination and eventually cellular fusion. This process is heavily regulated by such master transcription factors as MYOD and members of the MEF2 family. Here, we show that the transcription factor ZNF148 plays a direct role in human muscle cell differentiation. Downregulation of ZNF148 drives the formation of a muscle phenotype with rapid expression of myosin heavy chain, even in proliferative conditions. This phenotype was most likely mediated by the robust and swift upregulation of MYOD and MEF2C.

UR - http://www.scopus.com/inward/record.url?scp=85027508922&partnerID=8YFLogxK

U2 - 10.1038/s41598-017-08267-5

DO - 10.1038/s41598-017-08267-5

M3 - Article

C2 - 28811660

AN - SCOPUS:85027508922

SN - 2045-2322

VL - 7

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 8138

ER -

Transcription factor ZNF148 is a negative regulator of human muscle differentiation

Abstract

Access to Document

Other files and links

Fingerprint

Cite this