To the Editor: Immunologic abnormalities characteristic of AIDS, including the lowering or inversion of the ratio of helper to suppressor T lymphocytes, and diminished natural-killer-cell activity have been detected in otherwise healthy subjects with hemophilia who receive clotting factor, and in subjects with congenital anemias who receive repeated blood transfusions.1 2 3 Because both groups are known to be at risk of infection with the blood-borne virus responsible for AIDS, the question arises whether the immunologic abnormalities detected in these subjects developed as a result of infection with the AIDS-associated retrovirus or as a consequence of repeated transfusion. To address this issue.
|Number of pages||1|
|Journal||New England Journal of Medicine|
|State||Published - Nov 7 1985|