Transfusion-Induced Immunologic Abnormalities Not Related to AIDS Virus

Joseph Kaplan, Sharada Sarnaik, Jay Levy

Research output: Contribution to journalLetterpeer-review

4 Scopus citations


To the Editor: Immunologic abnormalities characteristic of AIDS, including the lowering or inversion of the ratio of helper to suppressor T lymphocytes, and diminished natural-killer-cell activity have been detected in otherwise healthy subjects with hemophilia who receive clotting factor, and in subjects with congenital anemias who receive repeated blood transfusions.1 2 3 Because both groups are known to be at risk of infection with the blood-borne virus responsible for AIDS, the question arises whether the immunologic abnormalities detected in these subjects developed as a result of infection with the AIDS-associated retrovirus or as a consequence of repeated transfusion. To address this issue.

Original languageEnglish
Pages (from-to)1227
Number of pages1
JournalNew England Journal of Medicine
Issue number19
StatePublished - Nov 7 1985


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