Translating biomarkers from research to clinical use in pediatric neurocritical care: Focus on traumatic brain injury and cardiac arrest

Andrew J. Prout, Michael S. Wolf, Ericka L. Fink

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Purpose of review Traumatic brain injury (TBI) and cardiac arrest are important causes of morbidity and mortality in children. Improved diagnosis and outcome prognostication using validated biomarkers could allow clinicians to better tailor therapies for optimal efficacy. Recent findings Contemporary investigation has yielded plentiful biomarker candidates of central nervous system (CNS) injury, including macromolecules, genetic, inflammatory, oxidative, and metabolic biomarkers. Biomarkers have yet to be validated and translated into bedside point-of-care or cost-effective and efficient laboratory tests. Validation testing should consider developmental status, injury mechanism, and time trajectory with patient-centered outcomes. Summary Recent investigation of biomarkers of CNS injury may soon improve diagnosis, management, and prognostication in children with traumatic brain injury and cardiac arrest.

Original languageEnglish
Pages (from-to)272-279
Number of pages8
JournalCurrent Opinion in Pediatrics
Volume29
Issue number3
DOIs
StatePublished - Jun 1 2017
Externally publishedYes

Keywords

  • biomarker
  • cardiac arrest
  • traumatic brain injury

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