Treatment of Refractory Infantile Hemangiomas and Pulmonary Hypertension with Sirolimus in a Pediatric Patient

Kelley K. Hutchins, Robert D. Ross, Daisuke Kobayashi, Alissa Martin, Madhvi Rajpurkar

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Infantile hemangioma is a benign vascular neoplasm that spontaneously involutes over time. Management, when needed, consists of medications, laser treatment and surgical excision. We describe a 3-year-old girl who presented shortly after birth with diffuse cutaneous hemangiomas, hepatosplenomegaly with liver lesions, anemia, and acute heart failure. She was diagnosed with hepatic and cutaneous infantile hemangioma based on skin biopsy. She developed progressive pulmonary hypertension with numerous pulmonary nodules suspicious for pulmonary arteriovenous malformations. She was started on sirolimus and had significant improvement in her pulmonary hypertension and liver lesions. This report supports prior studies that sirolimus is effective for vascular anomalies including IH refractory to conventional therapy.

Original languageEnglish
Pages (from-to)e391-e393
JournalJournal of Pediatric Hematology/Oncology
Volume39
Issue number7
DOIs
StatePublished - 2017

Keywords

  • infantile hemangioma
  • mTOR inhibitor
  • pulmonary hypertension
  • sirolimus

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