Treatment of seizures in childhood

Lalitha Sivaswamy, Gyula Acsadi, Huyian Jiang

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


The field of pediatric epilepsy is a rewarding yet challenging area of medicine. A fairly significant proportion of children remain refractory to current antiepileptic drugs, and may require alternative treatment options. Challenges also arise because many of the antiepileptic drugs available for use since 1993 are US FDA approved only for use over the age of 2-4 years, hence presenting a medicolegal conundrum to the treating physician. However, their more favorable side-effect profile and tolerability have led to their widespread use even in those less than 2 years of age. This review briefly outlines their indications, pharmacokinetic profile and dosages, and covers evidence-based guidelines for therapy in common epilepsy syndromes of childhood.

Original languageEnglish
Pages (from-to)41-50
Number of pages10
Issue number1
StatePublished - Jan 2009


  • Antiepileptic drugs
  • Generalized epilepsy
  • Infantile spasms
  • Ketogenic diet
  • Neonatal seizures
  • Partial epilepsy
  • Pediatric epilepsy
  • Status epilepticus
  • Surgical treatment of epilepsy
  • Vagal nerve stimulator


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