Treatment of vancomycin overdose using high-efficiency dialysis membranes

Timothy E. Bunchmam, Rudolph P. Valentini, John Gardner, Theresa Mottes, Timothy Kudelka, Norma J. Maxvold

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Two children underwent acute hemodialysis using high-efficiency dialysis membranes for vancomycin intoxication (plasma levels 238 μg/ml and 182 μg/ml). During a 3-h treatment, plasma vancomycin removal was on average 60%, with a calculated vancomycin half-life (t(1/2)) of 2 h. This is in contrast to a recent report using charcoal hemoperfusion for vancomycin intoxication (plasma level of 137 μg/ml), which resulted in a 40% relative plasma clearance and a calculated vancomycin t(1/2) of 12.5 h for a 4-h treatment. The choice of optimal modality for clearing a toxin should take into account the availability of equipment, protein or lipid binding of the toxin, and inherent risks of charcoal hemofiltration (large extracorporeal circuit, reversible hypocalcemia,heat loss, reversible coagulation defects) versus risks of high-efficiency hemodialysis (large extracorporeal circuit).

Original languageEnglish
Pages (from-to)773-774
Number of pages2
JournalPediatric Nephrology
Volume13
Issue number9
DOIs
StatePublished - Nov 1999

Keywords

  • High-efficiency dialysis membranes
  • Vancomycin intoxication

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