Unusual Presentation of Thrombotic Thrombocytopenic Purpura in a Newly Diagnosed Pediatric Patient with Systemic Lupus Erythematosus in the Setting of MIS-C

Eman T. Al-Antary, Rewa Arar, Yogindra Persaud, Basil M. Fathalla, Madhvi Rajpurkar, Kanta Bhambhani

Research output: Contribution to journalArticlepeer-review

Abstract

The understanding of coronavirus disease 2019 (COVID-19) immune dysregulation is evolving. Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with alternations in both innate and adaptive immunity, probably caused by a complex interplay of genetics and environmental exposure with various triggers. A rare hematological complication of SLE as well as recently reported in an adult with COVID-19 is thrombotic thrombocytopenic purpura. We report a pediatric case with features suggestive of the multisystem inflammatory syndrome in children with coronary artery ectasia, thrombotic thrombocytopenic purpura, and new-onset SLE.

Original languageEnglish
Pages (from-to)E812-E815
JournalJournal of Pediatric Hematology/Oncology
Volume44
Issue number3
DOIs
StatePublished - Apr 1 2022
Externally publishedYes

Keywords

  • COVID-19
  • MIS-C
  • SLE
  • TTP

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