Use and outcomes of cerebral embolic protection for transcatheter aortic valve replacement: A US nationwide study

Muhammad Zia Khan, Salman Zahid, Muhammad U. Khan, Asim Kichloo, Waqas Ullah, Yasar Sattar, Muhammad Bilal Munir, Atul Singla, Andrew M. Goldsweig, Sudarshan Balla

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: Outcomes data on the use of cerebral embolic protection devices (CPDs) with transcatheter aortic valve replacement (TAVR) remain limited. Previous randomized trials were underpowered for primary outcomes of stroke prevention and mortality. Methods: The National Inpatient Sample and Nationwide Readmissions Database were queried from 2017 to 2018 to study utilization and inpatient mortality, neurological complications (ischemic stroke, hemorrhagic stroke, and transient ischemic attack), procedural complications, resource utilization, and 30-day readmissions with and without use of CPD. A 1:3 ratio propensity score matched model was created. Results: Among 108,315 weighted encounters, CPD was used in 4380 patients (4.0%). Adjusted mortality was lower in patients undergoing TAVR with CPD (1.3% vs. 0.5%, p < 0.01). Neurological complications (2.5% vs. 1.7%, p < 0.01), hemorrhagic stroke (0.2% vs. 0%, p < 0.01) and ischemic stroke (2.2% vs. 1.4%, p < 0.01) were also lower in TAVR with CPD. Multiple logistic regression showed CPD use was associated with lower adjusted mortality (odds ratio (OR], 0.34 [95% confidence interval [CI], 0.22–0.52), p < 0.01) and lower adjusted neurological complications (OR, 0.68 (95% CI, 0.54–0.85], p < 0.01). On adjusted analysis, 30-day all-cause readmissions (Hazard ratio, HR 0.839, [95% CI, 0.773–0.911], p < 0.01) and stroke (HR, 0.727 [95% CI, 0.554–0.955), p = 0.02) were less likely in TAVR with CPD. Conclusion: We report real-world data on utilization and in-hospital outcomes of CPD use in TAVR. CPD use is associated with lower inpatient mortality, neurological, and clinical complications as compared to TAVR without CPD.

Original languageEnglish
Pages (from-to)959-968
Number of pages10
JournalCatheterization and Cardiovascular Interventions
Volume98
Issue number5
DOIs
StatePublished - Nov 1 2021

Keywords

  • aortic valve disease
  • embolic protection devices
  • percutaneous intervention
  • percutaneous valve therapy
  • transcatheter valve implantation

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