Use of polyamidoamine dendrimers in brain diseases

Maria Florendo; Alexander Figacz; Bhairavi Srinageshwar; Ajit Sharma; Douglas Swanson; Gary L. Dunbar; Julien Rossignol

doi:10.3390/molecules23092238

Use of polyamidoamine dendrimers in brain diseases

Maria Florendo, Alexander Figacz, Bhairavi Srinageshwar, Ajit Sharma, Douglas Swanson, Gary L. Dunbar, Julien Rossignol

Research output: Contribution to journal › Review article › peer-review

49 Scopus citations

Abstract

Polyamidoamine (PAMAM) dendrimers are one of the smallest and most precise nanomolecules available today, which have promising applications for the treatment of brain diseases. Each aspect of the dendrimer (core, size or generation, size of cavities, and surface functional groups) can be precisely modulated to yield a variety of nanocarriers for delivery of drugs and genes to brain cells in vitro or in vivo. Two of the most important criteria to consider when using PAMAM dendrimers for neuroscience applications is their safety profile and their potential to be prepared in a reproducible manner. Based on these criteria, features of PAMAM dendrimers are described to help the neuroscience researcher to judiciously choose the right type of dendrimer and the appropriate method for loading the drug to form a safe and effective delivery system to the brain.

Original language	English
Article number	2238
Journal	Molecules
Volume	23
Issue number	9
DOIs	https://doi.org/10.3390/molecules23092238
State	Published - Sep 3 2018

Keywords

Blood-brain barrier
DNA delivery
Drug delivery
Nanoparticles
Neurodegenerative diseases
PAMAM dendrimers

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10.3390/molecules23092238

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title = "Use of polyamidoamine dendrimers in brain diseases",

abstract = "Polyamidoamine (PAMAM) dendrimers are one of the smallest and most precise nanomolecules available today, which have promising applications for the treatment of brain diseases. Each aspect of the dendrimer (core, size or generation, size of cavities, and surface functional groups) can be precisely modulated to yield a variety of nanocarriers for delivery of drugs and genes to brain cells in vitro or in vivo. Two of the most important criteria to consider when using PAMAM dendrimers for neuroscience applications is their safety profile and their potential to be prepared in a reproducible manner. Based on these criteria, features of PAMAM dendrimers are described to help the neuroscience researcher to judiciously choose the right type of dendrimer and the appropriate method for loading the drug to form a safe and effective delivery system to the brain.",

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author = "Maria Florendo and Alexander Figacz and Bhairavi Srinageshwar and Ajit Sharma and Douglas Swanson and Dunbar, {Gary L.} and Julien Rossignol",

note = "Funding Information: Support for this study was provided by the College of Medicine at Central Michigan University, the Field Neurosciences Institute, and the John G. Kulhavi Professorship in Neuroscience at Central Michigan University",

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AU - Figacz, Alexander

AU - Srinageshwar, Bhairavi

AU - Sharma, Ajit

AU - Swanson, Douglas

AU - Dunbar, Gary L.

AU - Rossignol, Julien

N1 - Funding Information: Support for this study was provided by the College of Medicine at Central Michigan University, the Field Neurosciences Institute, and the John G. Kulhavi Professorship in Neuroscience at Central Michigan University

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N2 - Polyamidoamine (PAMAM) dendrimers are one of the smallest and most precise nanomolecules available today, which have promising applications for the treatment of brain diseases. Each aspect of the dendrimer (core, size or generation, size of cavities, and surface functional groups) can be precisely modulated to yield a variety of nanocarriers for delivery of drugs and genes to brain cells in vitro or in vivo. Two of the most important criteria to consider when using PAMAM dendrimers for neuroscience applications is their safety profile and their potential to be prepared in a reproducible manner. Based on these criteria, features of PAMAM dendrimers are described to help the neuroscience researcher to judiciously choose the right type of dendrimer and the appropriate method for loading the drug to form a safe and effective delivery system to the brain.

AB - Polyamidoamine (PAMAM) dendrimers are one of the smallest and most precise nanomolecules available today, which have promising applications for the treatment of brain diseases. Each aspect of the dendrimer (core, size or generation, size of cavities, and surface functional groups) can be precisely modulated to yield a variety of nanocarriers for delivery of drugs and genes to brain cells in vitro or in vivo. Two of the most important criteria to consider when using PAMAM dendrimers for neuroscience applications is their safety profile and their potential to be prepared in a reproducible manner. Based on these criteria, features of PAMAM dendrimers are described to help the neuroscience researcher to judiciously choose the right type of dendrimer and the appropriate method for loading the drug to form a safe and effective delivery system to the brain.

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KW - DNA delivery

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Use of polyamidoamine dendrimers in brain diseases

Abstract

Keywords

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