TY - JOUR
T1 - Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia
AU - on behalf of the Children’s Hospitals Neonatal Consortium Severe BPD Focus Group
AU - Vyas-Read, Shilpa
AU - Wymore, Erica M.
AU - Zaniletti, Isabella
AU - Murthy, Karna
AU - Padula, Michael A.
AU - Truog, William E.
AU - Engle, William A.
AU - Savani, Rashmin C.
AU - Yallapragada, Sushmita
AU - Logan, J. Wells
AU - Zhang, Huayan
AU - Hysinger, Erik B.
AU - Grover, Theresa R.
AU - Natarajan, Girija
AU - Nelin, Leif D.
AU - Porta, Nicolas F.M.
AU - Potoka, Karin P.
AU - DiGeronimo, Robert
AU - Lagatta, Joanne M.
N1 - Publisher Copyright:
© 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Objective: To determine the relationship between interventricular septal position (SP) and right ventricular systolic pressure (RVSP) and mortality in infants with severe BPD (sBPD). Study design: Infants with sBPD in the Children’s Hospitals Neonatal Database who had echocardiograms 34–44 weeks’ postmenstrual age (PMA) were included. SP and RVSP were categorized normal, abnormal (flattened/bowed SP or RVSP > 40 mmHg) or missing. Results: Of 1157 infants, 115 infants (10%) died. Abnormal SP or RVSP increased mortality (SP 19% vs. 8% normal/missing, RVSP 20% vs. 9% normal/missing, both p < 0.01) in unadjusted and multivariable models, adjusted for significant covariates (SP OR 1.9, 95% CI 1.2–3.0; RVSP OR 2.2, 95% CI 1.1–4.7). Abnormal parameters had high specificity (SP 82%; RVSP 94%), and negative predictive value (SP 94%, NPV 91%) for mortality. Conclusions: Abnormal SP or RVSP is independently associated with mortality in sBPD infants. Negative predictive values distinguish infants most likely to survive.
AB - Objective: To determine the relationship between interventricular septal position (SP) and right ventricular systolic pressure (RVSP) and mortality in infants with severe BPD (sBPD). Study design: Infants with sBPD in the Children’s Hospitals Neonatal Database who had echocardiograms 34–44 weeks’ postmenstrual age (PMA) were included. SP and RVSP were categorized normal, abnormal (flattened/bowed SP or RVSP > 40 mmHg) or missing. Results: Of 1157 infants, 115 infants (10%) died. Abnormal SP or RVSP increased mortality (SP 19% vs. 8% normal/missing, RVSP 20% vs. 9% normal/missing, both p < 0.01) in unadjusted and multivariable models, adjusted for significant covariates (SP OR 1.9, 95% CI 1.2–3.0; RVSP OR 2.2, 95% CI 1.1–4.7). Abnormal parameters had high specificity (SP 82%; RVSP 94%), and negative predictive value (SP 94%, NPV 91%) for mortality. Conclusions: Abnormal SP or RVSP is independently associated with mortality in sBPD infants. Negative predictive values distinguish infants most likely to survive.
UR - http://www.scopus.com/inward/record.url?scp=85074329638&partnerID=8YFLogxK
U2 - 10.1038/s41372-019-0508-5
DO - 10.1038/s41372-019-0508-5
M3 - Article
C2 - 31570799
AN - SCOPUS:85074329638
VL - 40
SP - 149
EP - 156
JO - Journal of Perinatology
JF - Journal of Perinatology
SN - 0743-8346
IS - 1
ER -