Vacuolated neuroblastoma cells mimicking FAB L3 lymphoblasts in bone marrow aspirates

Patricia Alcasabas, Andrew Dettore, Bülent Özgönenel, Kanta Bhambhani, Yaddanapudi Ravindranath, Süreyya Savaşan

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Abundant cytoplasmic vacuolation of neuroblasts has been noted on bone marrow aspirate (BMA) smears of two patients with metastatic neuroblastoma. Occasional tumor cells were dispersed as individual cells as well as in clumps. These cells had basophilic cytoplasm and several nucleoli, reminiscent of L 3 lymphoblast morphology. Flow cytometric analysis of the bone marrow mononuclear cells and neuron-specific enolase staining of the bone marrow biopsy samples further distinguished the cells as neuroblasts. Cytoplasmic vacuolations of neuroblasts may be a feature of metastatic neuroblastoma cells in BMA smears.

Original languageEnglish
Pages (from-to)227-229
Number of pages3
JournalPediatric Blood and Cancer
Issue number2
StatePublished - Feb 2007


  • Acute lymphoblastic leukemia
  • Bone marrow aspiration
  • Cytoplasmic vacuolation
  • L3 type
  • Neuroblastoma


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