Abstract
C-H bond can undergo vicarious Michael addition reaction (VMA) with double-activated double bond in the absence of strong base and catalyst under mild conditions. Intramolecular H-bonding, electron-withdrawing inductive effect, and steric hindrance at α-position of nucleophile facilitates C-H addition over N-H addition. By using VMA, high branching multiplicity, novel branching pattern, controllable density and distribution of functional groups can be envisioned for novel dendrimer synthesis.
| Original language | English |
|---|---|
| Pages (from-to) | 561-564 |
| Number of pages | 4 |
| Journal | Chinese Chemical Letters |
| Volume | 17 |
| Issue number | 4 |
| State | Published - Apr 2006 |
Keywords
- C-H bond activation
- Dendrimers
- Hydrogen bonds
- Michael addition
- Synthesis