Abstract
Abstract: Riboflavin (vitamin B2) is converted into the enzymatic cofactors flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) in vivo. All three compounds contain the flavin heterocycle, which is essential to the function of numerous enzymes. A clear understanding of flavin biochemical mechanisms has been elusive despite decades of research. When riboflavin is irradiated in dimethyl sulfoxide (DMSO) a lumichrome-DMSO adduct forms. When ascorbic acid is added to the reaction, the lumichrome-DMSO adduct is replaced by a lumichrome-ascorbic acid adduct. However, when an alkyne is added in place of ascorbic acid, a different type of photo-adduct is formed between the flavin and alkyne that is not a lumichrome. The structure of these adducts is being investigated by UV-Vis, NMR, and ESI-MS and progress will be reported.
| Original language | English |
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| State | Published - Aug 2023 |
| Event | American Chemical Society National Meeting - Chicago, Illinois Duration: Aug 1 2023 → Aug 31 2023 |
Conference
| Conference | American Chemical Society National Meeting |
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| Period | 08/1/23 → 08/31/23 |