Virus-induced inhibition of CD1d1-mediated antigen presentation: Reciprocal regulation by p38 and ERK

Gourapura J. Renukaradhya; Tonya J.Roberts Webb; Masood A. Khan; Yin Ling Lin; Wenjun Du; Jacquelyn Gervay-Hague; Randy R. Brutkiewicz

doi:10.4049/jimmunol.175.7.4301

Virus-induced inhibition of CD1d1-mediated antigen presentation: Reciprocal regulation by p38 and ERK

Gourapura J. Renukaradhya, Tonya J.Roberts Webb, Masood A. Khan, Yin Ling Lin, Wenjun Du, Jacquelyn Gervay-Hague, Randy R. Brutkiewicz

https://www.cmich.edu/academics/colleges/college-science-engineering/departments-schools/chemistry-and-biochemistry

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

A critical component of the host's innate immune response involves lipid Ag presentation by CD1d molecules to NK T cells. In this study we used murine CD1d1-transfected L (L-CD1) cells to study the effect of viruses on CD1d-mediated Ag presentation to NKT cells and found that an infection with vesicular stomatitis and vaccinia (but not lymphocytic choriomeningitis) virus inhibited murine CD1d1-mediated Ag presentation. This was under the reciprocal control of the MAPKs, p38 and ERK, and was due to changes in the intracellular trafficking of CD1d1. The reciprocal regulation of CD1d1-mediatcd Ag presentation by MAPK suggests that the targeting of these pathways is a novel means of immune evasion by viruses.

Original language	English
Pages (from-to)	4301-4308
Number of pages	8
Journal	Journal of Immunology
Volume	175
Issue number	7
DOIs	https://doi.org/10.4049/jimmunol.175.7.4301
State	Published - Oct 1 2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.4049/jimmunol.175.7.4301

Cite this

@article{6f20fa31d1174d559a94f1a7c919f2d7,

title = "Virus-induced inhibition of CD1d1-mediated antigen presentation: Reciprocal regulation by p38 and ERK",

abstract = "A critical component of the host's innate immune response involves lipid Ag presentation by CD1d molecules to NK T cells. In this study we used murine CD1d1-transfected L (L-CD1) cells to study the effect of viruses on CD1d-mediated Ag presentation to NKT cells and found that an infection with vesicular stomatitis and vaccinia (but not lymphocytic choriomeningitis) virus inhibited murine CD1d1-mediated Ag presentation. This was under the reciprocal control of the MAPKs, p38 and ERK, and was due to changes in the intracellular trafficking of CD1d1. The reciprocal regulation of CD1d1-mediatcd Ag presentation by MAPK suggests that the targeting of these pathways is a novel means of immune evasion by viruses.",

author = "Renukaradhya, {Gourapura J.} and Webb, {Tonya J.Roberts} and Khan, {Masood A.} and Lin, {Yin Ling} and Wenjun Du and Jacquelyn Gervay-Hague and Brutkiewicz, {Randy R.}",

year = "2005",

month = oct,

day = "1",

doi = "10.4049/jimmunol.175.7.4301",

language = "English",

volume = "175",

pages = "4301--4308",

journal = "Journal of Immunology",

issn = "0022-1767",

publisher = "Journal of Immunology",

number = "7",

}

TY - JOUR

T1 - Virus-induced inhibition of CD1d1-mediated antigen presentation

T2 - Reciprocal regulation by p38 and ERK

AU - Renukaradhya, Gourapura J.

AU - Webb, Tonya J.Roberts

AU - Khan, Masood A.

AU - Lin, Yin Ling

AU - Du, Wenjun

AU - Gervay-Hague, Jacquelyn

AU - Brutkiewicz, Randy R.

PY - 2005/10/1

Y1 - 2005/10/1

N2 - A critical component of the host's innate immune response involves lipid Ag presentation by CD1d molecules to NK T cells. In this study we used murine CD1d1-transfected L (L-CD1) cells to study the effect of viruses on CD1d-mediated Ag presentation to NKT cells and found that an infection with vesicular stomatitis and vaccinia (but not lymphocytic choriomeningitis) virus inhibited murine CD1d1-mediated Ag presentation. This was under the reciprocal control of the MAPKs, p38 and ERK, and was due to changes in the intracellular trafficking of CD1d1. The reciprocal regulation of CD1d1-mediatcd Ag presentation by MAPK suggests that the targeting of these pathways is a novel means of immune evasion by viruses.

AB - A critical component of the host's innate immune response involves lipid Ag presentation by CD1d molecules to NK T cells. In this study we used murine CD1d1-transfected L (L-CD1) cells to study the effect of viruses on CD1d-mediated Ag presentation to NKT cells and found that an infection with vesicular stomatitis and vaccinia (but not lymphocytic choriomeningitis) virus inhibited murine CD1d1-mediated Ag presentation. This was under the reciprocal control of the MAPKs, p38 and ERK, and was due to changes in the intracellular trafficking of CD1d1. The reciprocal regulation of CD1d1-mediatcd Ag presentation by MAPK suggests that the targeting of these pathways is a novel means of immune evasion by viruses.

UR - http://www.scopus.com/inward/record.url?scp=25444514465&partnerID=8YFLogxK

U2 - 10.4049/jimmunol.175.7.4301

DO - 10.4049/jimmunol.175.7.4301

M3 - Article

C2 - 16177070

AN - SCOPUS:25444514465

SN - 0022-1767

VL - 175

SP - 4301

EP - 4308

JO - Journal of Immunology

JF - Journal of Immunology

IS - 7

ER -

Virus-induced inhibition of CD1d1-mediated antigen presentation: Reciprocal regulation by p38 and ERK

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this