TY - JOUR
T1 - Weak extremely‐low‐frequency magnetic fields and regeneration in the planarian Dugesia tigrina
AU - Jenrow, K. A.
AU - Smith, C. H.
AU - Liboff, A. R.
PY - 1995
Y1 - 1995
N2 - Extremely‐low‐frequency (ELF), low‐intensity magnetic fields have been shown to influence cell signaling processes in a variety of systems, both in vivo and in vitro. Similar effects have been demonstrated for nervous system development and neurite outgrowth. We report that regeneration in planaria, which incorporates many of these processes, is also affected by ELF magnetic fields. The rate of cephalic regeneration, reflected by the mean regeneration time (MRT), for planaria populations regenerating under continuous exposure to combined DC (78.4 μT) and AC (60.0 Hz at 10.0 μT peak) magnetic fields applied in parallel was found to be significantly delayed (P ≪ 0.001) by 48 ± 1 h relative to two different types of control populations (MRT ˜ 140 ± 12 h). One control population was exposed to only the AC component of this field combination, while the other experienced only the ambient geomagnetic field. All measurements were conducted in a low‐gradient, low‐noise magnetics laboratory under well‐maintained temperature conditions. This delay in regeneration was shown to be dependent on the planaria having a fixed orientation with respect to the magnetic field vectors. Results also indicate that this orientation‐dependent transduction process does not result from Faraday induction but is consistent with a Ca2+ cyclotron resonance mechanism. Data interpretation also permits the tentative conclusion that the effect results from an inhibition of events at an early stage in the regeneration process before the onset of proliferation and differentiation. © 1995 Wiley‐Liss, Inc.
AB - Extremely‐low‐frequency (ELF), low‐intensity magnetic fields have been shown to influence cell signaling processes in a variety of systems, both in vivo and in vitro. Similar effects have been demonstrated for nervous system development and neurite outgrowth. We report that regeneration in planaria, which incorporates many of these processes, is also affected by ELF magnetic fields. The rate of cephalic regeneration, reflected by the mean regeneration time (MRT), for planaria populations regenerating under continuous exposure to combined DC (78.4 μT) and AC (60.0 Hz at 10.0 μT peak) magnetic fields applied in parallel was found to be significantly delayed (P ≪ 0.001) by 48 ± 1 h relative to two different types of control populations (MRT ˜ 140 ± 12 h). One control population was exposed to only the AC component of this field combination, while the other experienced only the ambient geomagnetic field. All measurements were conducted in a low‐gradient, low‐noise magnetics laboratory under well‐maintained temperature conditions. This delay in regeneration was shown to be dependent on the planaria having a fixed orientation with respect to the magnetic field vectors. Results also indicate that this orientation‐dependent transduction process does not result from Faraday induction but is consistent with a Ca2+ cyclotron resonance mechanism. Data interpretation also permits the tentative conclusion that the effect results from an inhibition of events at an early stage in the regeneration process before the onset of proliferation and differentiation. © 1995 Wiley‐Liss, Inc.
KW - extremely low frequency (ELF)
KW - ion cyclotron resonance
KW - magnetic field
KW - orientation
KW - planarian regeneration
UR - http://www.scopus.com/inward/record.url?scp=0029174117&partnerID=8YFLogxK
U2 - 10.1002/bem.2250160206
DO - 10.1002/bem.2250160206
M3 - Article
C2 - 7612025
AN - SCOPUS:0029174117
VL - 16
SP - 106
EP - 112
JO - Bioelectromagnetics
JF - Bioelectromagnetics
SN - 0197-8462
IS - 2
ER -