When should antithrombotic therapy be resumed after gastrointestinal bleeding?

Arestarting antithrombotic therapy is recommended when indicated in patients after gastrointestinal bleeding, such as those with acute coronary syndromes or atrial fi brillation, or following percutaneous intervention.1 However, the timing is critical, as premature re-initiation can lead to recurrent bleeding, and delayed re-initiation can increase risk of thromboembolic events. Antithrombotic therapy decreases unfavorable outcomes secondary to underlying etiology.¹ The timing of re-initiating therapy after gastrointestinal bleeding warrants an individualized approach. The plan may be modifi ed after consideration of factors related to the bleeding event, thromboembolic risk, and patient comorbidities.¹